| Date | Home | Away | Result |
|---|---|---|---|
| 02/09/22 19:30 | Borussia Dortmund | 1899 Hoffenheim | 1-0 |
| 03/09/22 14:30 | VfL Wolfsburg | 1. FC Köln | 2-4 |
| 03/09/22 14:30 | 1. FC Union Berlin | FC Bayern Munich | 1-1 |
| 03/09/22 14:30 | VfB Stuttgart | FC Schalke 04 | 1-1 |
| 03/09/22 14:30 | Bayer 04 Leverkusen | SC Freiburg | 2-3 |
| 03/09/22 14:30 | VfL Bochum | Werder Bremen | 0-2 |
| 03/09/22 17:30 | Eintracht Frankfurt | RB Leipzig | 4-0 |
| 04/09/22 14:30 | FC Augsburg | Hertha BSC | 0-2 |
| 04/09/22 16:30 | Bor. Mönchengladbach | FSV Mainz 05 | 0-1 |