Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| 2.BL | 15/10/21 17:30 | 15/10/21 17:30 | Hannover 96 | FC Schalke 04 | 0-1 | 2 - 4 points |
| GER1 | 15/10/21 19:30 | 15/10/21 19:30 | 1899 Hoffenheim | 1. FC Köln | 5-0 | 2 - 4 points |
| 2.BL | 16/10/21 12:30 | 16/10/21 12:30 | 1. FC Heidenheim 1846 | FC St. Pauli | 2-4 | 2 - 4 points |
| 2.BL | 16/10/21 12:30 | 16/10/21 12:30 | FC Ingolstadt | Holstein Kiel | 1-1 | 2 - 4 points |
| GER1 | 16/10/21 14:30 | 16/10/21 14:30 | 1. FC Union Berlin | VfL Wolfsburg | 2-0 | 2 - 4 points |
| GER1 | 16/10/21 14:30 | 16/10/21 14:30 | Eintracht Frankfurt | Hertha BSC | 1-2 | 2 - 4 points |
| GER1 | 16/10/21 14:30 | 16/10/21 14:30 | Borussia Dortmund | FSV Mainz 05 | 3-1 | 2 - 4 points |
| GER1 | 16/10/21 14:30 | 16/10/21 14:30 | SpVgg Greuther Fürth | VfL Bochum | 0-1 | 2 - 4 points |
| GER1 | 16/10/21 14:30 | 16/10/21 14:30 | SC Freiburg | RB Leipzig | 1-1 | 2 - 4 points |
| GER1 | 16/10/21 17:30 | 16/10/21 17:30 | Bor. Mönchengladbach | VfB Stuttgart | 1-1 | 2 - 4 points |
| 2.BL | 16/10/21 19:30 | 16/10/21 19:30 | Hamburger SV | Fortuna Düsseldorf | 1-1 | 2 - 4 points |
| 2.BL | 17/10/21 12:30 | 17/10/21 12:30 | SV Darmstadt 98 | Werder Bremen | 3-0 | 2 - 4 points |
| GER1 | 17/10/21 14:30 | 17/10/21 14:30 | Bayer 04 Leverkusen | FC Bayern Munich | 1-5 | 2 - 4 points |
| GER1 | 17/10/21 16:30 | 17/10/21 16:30 | FC Augsburg | Arminia Bielefeld | 1-1 | 2 - 4 points |