Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/10/21 17:35 | 22/10/21 17:35 | FC Turin | FC Genua 1893 | 3-2 | 2 - 5 points |
| 22/10/21 19:45 | 22/10/21 19:45 | Sampdoria Genua | Spezia Calcio | 2-1 | 2 - 5 points |
| 23/10/21 14:00 | 23/10/21 14:00 | US Salernitana | FC Empoli | 2-4 | 2 - 5 points |
| 23/10/21 17:00 | 23/10/21 17:00 | Sassuolo Calcio | FC Venice | 3-1 | 2 - 5 points |
| 23/10/21 19:45 | 23/10/21 19:45 | FC Bologna | AC Milan | 2-4 | 2 - 5 points |
| 24/10/21 11:30 | 24/10/21 11:30 | Atalanta Bergamo | Udinese Calcio | 1-1 | 2 - 5 points |
| 24/10/21 14:00 | 24/10/21 14:00 | Fiorentina | Cagliari Calcio | 3-0 | 2 - 5 points |
| 24/10/21 14:00 | 24/10/21 14:00 | Hellas Verona | Lazio Rom | 4-1 | 2 - 5 points |
| 24/10/21 17:00 | 24/10/21 17:00 | AS Roma | SSC Napoli | 0-0 | 2 - 5 points |
| 24/10/21 19:50 | 24/10/21 19:50 | Inter Milan | Juventus Turin | 1-1 | 2 - 5 points |