Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 16/10/21 14:00 | 16/10/21 14:00 | Spezia Calcio | US Salernitana | 2-1 | 2 - 5 points |
| 16/10/21 17:00 | 16/10/21 17:00 | Lazio Rom | Inter Milan | 3-1 | 2 - 5 points |
| 16/10/21 19:50 | 16/10/21 19:50 | AC Milan | Hellas Verona | 3-2 | 2 - 5 points |
| 17/10/21 11:30 | 17/10/21 11:30 | Cagliari Calcio | Sampdoria Genua | 3-1 | 2 - 5 points |
| 17/10/21 14:00 | 17/10/21 14:00 | Udinese Calcio | FC Bologna | 1-1 | 2 - 5 points |
| 17/10/21 14:00 | 17/10/21 14:00 | FC Genua 1893 | Sassuolo Calcio | 2-2 | 2 - 5 points |
| 17/10/21 14:00 | 17/10/21 14:00 | FC Empoli | Atalanta Bergamo | 1-4 | 2 - 5 points |
| 17/10/21 17:05 | 17/10/21 17:05 | SSC Napoli | FC Turin | 1-0 | 2 - 5 points |
| 17/10/21 19:45 | 17/10/21 19:45 | Juventus Turin | AS Roma | 1-0 | 2 - 5 points |
| 18/10/21 19:45 | 18/10/21 19:45 | FC Venice | Fiorentina | 1-0 | 2 - 5 points |