Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 01/10/21 19:45 | 01/10/21 19:45 | Cagliari Calcio | FC Venice | 1-1 | 2 - 5 points |
| 02/10/21 14:05 | 02/10/21 14:05 | US Salernitana | FC Genua 1893 | 1-0 | 2 - 5 points |
| 02/10/21 17:00 | 02/10/21 17:00 | FC Turin | Juventus Turin | 0-1 | 2 - 5 points |
| 02/10/21 19:45 | 02/10/21 19:45 | Sassuolo Calcio | Inter Milan | 1-2 | 2 - 5 points |
| 03/10/21 11:30 | 03/10/21 11:30 | FC Bologna | Lazio Rom | 3-0 | 2 - 5 points |
| 03/10/21 14:00 | 03/10/21 14:00 | Sampdoria Genua | Udinese Calcio | 3-3 | 2 - 5 points |
| 03/10/21 14:00 | 03/10/21 14:00 | Hellas Verona | Spezia Calcio | 4-0 | 2 - 5 points |
| 03/10/21 17:00 | 03/10/21 17:00 | AS Roma | FC Empoli | 2-0 | 2 - 5 points |
| 03/10/21 17:05 | 03/10/21 17:05 | Fiorentina | SSC Napoli | 1-2 | 2 - 5 points |
| 03/10/21 19:45 | 03/10/21 19:45 | Atalanta Bergamo | AC Milan | 2-3 | 2 - 5 points |