Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/09/21 14:00 | 25/09/21 14:00 | Spezia Calcio | AC Milan | 1-2 | 2 - 5 points |
| 25/09/21 17:00 | 25/09/21 17:00 | Inter Milan | Atalanta Bergamo | 2-2 | 2 - 5 points |
| 25/09/21 19:45 | 25/09/21 19:45 | FC Genua 1893 | Hellas Verona | 3-3 | 2 - 5 points |
| 26/09/21 11:30 | 26/09/21 11:30 | Juventus Turin | Sampdoria Genua | 3-2 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | FC Empoli | FC Bologna | 4-2 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | Udinese Calcio | Fiorentina | 0-1 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | Sassuolo Calcio | US Salernitana | 1-0 | 2 - 5 points |
| 26/09/21 17:00 | 26/09/21 17:00 | Lazio Rom | AS Roma | 3-2 | 2 - 5 points |
| 26/09/21 19:45 | 26/09/21 19:45 | SSC Napoli | Cagliari Calcio | 2-0 | 2 - 5 points |
| 27/09/21 19:45 | 27/09/21 19:45 | FC Venice | FC Turin | 1-1 | 2 - 5 points |