Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/09/21 17:30 | 21/09/21 17:30 | FC Bologna | FC Genua 1893 | 2-2 | 2 - 5 points |
| 21/09/21 19:45 | 21/09/21 19:45 | Atalanta Bergamo | Sassuolo Calcio | 2-1 | 2 - 5 points |
| 21/09/21 19:45 | 21/09/21 19:45 | Fiorentina | Inter Milan | 1-3 | 2 - 5 points |
| 22/09/21 17:30 | 22/09/21 17:30 | Spezia Calcio | Juventus Turin | 2-3 | 2 - 5 points |
| 22/09/21 17:30 | 22/09/21 17:30 | US Salernitana | Hellas Verona | 2-2 | 2 - 5 points |
| 22/09/21 19:45 | 22/09/21 19:45 | Cagliari Calcio | FC Empoli | 0-2 | 2 - 5 points |
| 22/09/21 19:45 | 22/09/21 19:45 | AC Milan | FC Venice | 2-0 | 2 - 5 points |
| 23/09/21 17:30 | 23/09/21 17:30 | Sampdoria Genua | SSC Napoli | 0-4 | 2 - 5 points |
| 23/09/21 17:30 | 23/09/21 17:30 | FC Turin | Lazio Rom | 1-1 | 2 - 5 points |
| 23/09/21 19:45 | 23/09/21 19:45 | AS Roma | Udinese Calcio | 1-0 | 2 - 5 points |