Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 17/09/21 19:45 | 17/09/21 19:45 | Sassuolo Calcio | FC Turin | 0-1 | 2 - 5 points |
| 18/09/21 14:00 | 18/09/21 14:00 | FC Genua 1893 | Fiorentina | 1-2 | 2 - 5 points |
| 18/09/21 17:00 | 18/09/21 17:00 | Inter Milan | FC Bologna | 6-1 | 2 - 5 points |
| 18/09/21 19:45 | 18/09/21 19:45 | US Salernitana | Atalanta Bergamo | 0-1 | 2 - 5 points |
| 19/09/21 11:30 | 19/09/21 11:30 | FC Empoli | Sampdoria Genua | 0-3 | 2 - 5 points |
| 19/09/21 14:00 | 19/09/21 14:00 | FC Venice | Spezia Calcio | 1-2 | 2 - 5 points |
| 19/09/21 17:00 | 19/09/21 17:00 | Hellas Verona | AS Roma | 3-2 | 2 - 5 points |
| 19/09/21 17:00 | 19/09/21 17:00 | Lazio Rom | Cagliari Calcio | 2-2 | 2 - 5 points |
| 19/09/21 19:45 | 19/09/21 19:45 | Juventus Turin | AC Milan | 1-1 | 2 - 5 points |
| 20/09/21 19:45 | 20/09/21 19:45 | Udinese Calcio | SSC Napoli | 0-4 | 2 - 5 points |