Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/09/21 14:00 | 11/09/21 14:00 | FC Empoli | FC Venice | 1-2 | 2 - 5 points |
| 11/09/21 17:00 | 11/09/21 17:00 | SSC Napoli | Juventus Turin | 2-1 | 2 - 5 points |
| 11/09/21 19:45 | 11/09/21 19:45 | Atalanta Bergamo | Fiorentina | 1-2 | 2 - 5 points |
| 12/09/21 11:30 | 12/09/21 11:30 | Sampdoria Genua | Inter Milan | 2-2 | 2 - 5 points |
| 12/09/21 14:00 | 12/09/21 14:00 | FC Turin | US Salernitana | 4-0 | 2 - 5 points |
| 12/09/21 14:00 | 12/09/21 14:00 | Cagliari Calcio | FC Genua 1893 | 2-3 | 2 - 5 points |
| 12/09/21 14:00 | 12/09/21 14:00 | Spezia Calcio | Udinese Calcio | 0-1 | 2 - 5 points |
| 12/09/21 17:00 | 12/09/21 17:00 | AC Milan | Lazio Rom | 2-0 | 2 - 5 points |
| 12/09/21 19:45 | 12/09/21 19:45 | AS Roma | Sassuolo Calcio | 2-1 | 2 - 5 points |
| 13/09/21 19:45 | 13/09/21 19:45 | FC Bologna | Hellas Verona | 1-0 | 2 - 5 points |