Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 27/08/21 17:30 | 27/08/21 17:30 | Udinese Calcio | FC Venice | 3-0 | 2 - 5 points |
| 27/08/21 19:45 | 27/08/21 19:45 | Hellas Verona | Inter Milan | 1-3 | 2 - 5 points |
| 28/08/21 17:30 | 28/08/21 17:30 | Lazio Rom | Spezia Calcio | 6-1 | 2 - 5 points |
| 28/08/21 17:30 | 28/08/21 17:30 | Atalanta Bergamo | FC Bologna | 0-0 | 2 - 5 points |
| 28/08/21 19:45 | 28/08/21 19:45 | Juventus Turin | FC Empoli | 0-1 | 2 - 5 points |
| 28/08/21 19:45 | 28/08/21 19:45 | Fiorentina | FC Turin | 2-1 | 2 - 5 points |
| 29/08/21 17:30 | 29/08/21 17:30 | Sassuolo Calcio | Sampdoria Genua | 0-0 | 2 - 5 points |
| 29/08/21 17:30 | 29/08/21 17:30 | FC Genua 1893 | SSC Napoli | 1-2 | 2 - 5 points |
| 29/08/21 19:45 | 29/08/21 19:45 | US Salernitana | AS Roma | 0-4 | 2 - 5 points |
| 29/08/21 19:45 | 29/08/21 19:45 | AC Milan | Cagliari Calcio | 4-1 | 2 - 5 points |