Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/11/21 19:45 | 26/11/21 19:45 | Cagliari Calcio | US Salernitana | 1-1 | 2 - 5 points |
| 27/11/21 14:00 | 27/11/21 14:00 | FC Empoli | Fiorentina | 2-1 | 2 - 5 points |
| 27/11/21 14:00 | 27/11/21 14:00 | Sampdoria Genua | Hellas Verona | 3-1 | 2 - 5 points |
| 27/11/21 17:00 | 27/11/21 17:00 | Juventus Turin | Atalanta Bergamo | 0-1 | 2 - 5 points |
| 27/11/21 19:45 | 27/11/21 19:45 | FC Venice | Inter Milan | 0-2 | 2 - 5 points |
| 28/11/21 11:30 | 28/11/21 11:30 | Udinese Calcio | FC Genua 1893 | 0-0 | 2 - 5 points |
| 28/11/21 14:00 | 28/11/21 14:00 | AC Milan | Sassuolo Calcio | 1-3 | 2 - 5 points |
| 28/11/21 14:05 | 28/11/21 14:05 | Spezia Calcio | FC Bologna | 0-1 | 2 - 5 points |
| 28/11/21 17:00 | 28/11/21 17:00 | AS Roma | FC Turin | 1-0 | 2 - 5 points |
| 28/11/21 19:50 | 28/11/21 19:50 | SSC Napoli | Lazio Rom | 4-0 | 2 - 5 points |