Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 26/10/21 17:30 | 26/10/21 17:30 | FC Venice | US Salernitana | 1-2 | 2 - 5 points |
| 26/10/21 17:30 | 26/10/21 17:30 | Spezia Calcio | FC Genua 1893 | 1-1 | 2 - 5 points |
| 26/10/21 19:45 | 26/10/21 19:45 | AC Milan | FC Turin | 1-0 | 2 - 5 points |
| 27/10/21 17:30 | 27/10/21 17:30 | Udinese Calcio | Hellas Verona | 1-1 | 2 - 5 points |
| 27/10/21 17:30 | 27/10/21 17:30 | Juventus Turin | Sassuolo Calcio | 1-2 | 2 - 5 points |
| 27/10/21 17:35 | 27/10/21 17:35 | Sampdoria Genua | Atalanta Bergamo | 1-3 | 2 - 5 points |
| 27/10/21 19:45 | 27/10/21 19:45 | Cagliari Calcio | AS Roma | 1-2 | 2 - 5 points |
| 27/10/21 19:45 | 27/10/21 19:45 | FC Empoli | Inter Milan | 0-2 | 2 - 5 points |
| 27/10/21 19:45 | 27/10/21 19:45 | Lazio Rom | Fiorentina | 1-0 | 2 - 5 points |
| 28/10/21 19:45 | 28/10/21 19:45 | SSC Napoli | FC Bologna | 3-0 | 2 - 5 points |