Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 21/08/21 17:30 | 21/08/21 17:30 | Hellas Verona | Sassuolo Calcio | 2-3 | 2 - 5 points |
| 21/08/21 17:30 | 21/08/21 17:30 | Inter Milan | Genua CFC | 4-0 | 2 - 5 points |
| 21/08/21 19:45 | 21/08/21 19:45 | FC Turin | Atalanta Bergamo | 1-2 | 2 - 5 points |
| 21/08/21 19:45 | 21/08/21 19:45 | FC Empoli | Lazio Rom | 1-3 | 2 - 5 points |
| 22/08/21 17:30 | 22/08/21 17:30 | FC Bologna | US Salernitana | 3-2 | 2 - 5 points |
| 22/08/21 17:30 | 22/08/21 17:30 | Udinese Calcio | Juventus Turin | 2-2 | 2 - 5 points |
| 22/08/21 19:45 | 22/08/21 19:45 | SSC Napoli | FC Venice | 2-0 | 2 - 5 points |
| 22/08/21 19:45 | 22/08/21 19:45 | AS Roma | Fiorentina | 3-1 | 2 - 5 points |
| 23/08/21 17:30 | 23/08/21 17:30 | Cagliari Calcio | Spezia Calcio | 2-2 | 2 - 5 points |
| 23/08/21 19:45 | 23/08/21 19:45 | Sampdoria Genua | AC Milan | 0-1 | 2 - 5 points |