Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 25/09/21 16:00 | 25/09/21 16:00 | AS St. Etienne | OGC Nice | 0-3 | 2 - 5 points |
| 25/09/21 18:00 | 25/09/21 18:00 | Racing Club Strasbourg | OSC Lille | 1-2 | 2 - 5 points |
| 25/09/21 20:00 | 25/09/21 20:00 | Olympique Lyon | FC Lorient | 1-1 | 2 - 5 points |
| 25/09/21 20:00 | 25/09/21 20:00 | Paris St. Germain | HSC Montpellier | 2-0 | 2 - 5 points |
| 26/09/21 12:00 | 26/09/21 12:00 | Girondins Bordeaux | Stade Rennes | 1-1 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | ES Troyes AC | SCO Angers | 1-1 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | Stade Brest 29 | FC Metz | 1-2 | 2 - 5 points |
| 26/09/21 14:00 | 26/09/21 14:00 | Stade Reims | FC Nantes | 3-1 | 2 - 5 points |
| 26/09/21 16:05 | 26/09/21 16:05 | Clermont Foot | AS Monaco | 1-3 | 2 - 5 points |
| 26/09/21 19:45 | 26/09/21 19:45 | Olympique Marseille | RC Lens | 2-3 | 2 - 5 points |