Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/09/21 18:00 | 22/09/21 18:00 | FC Nantes | Stade Brest 29 | 3-1 | 2 - 5 points |
| 22/09/21 18:00 | 22/09/21 18:00 | Stade Rennes | Clermont Foot | 6-0 | 2 - 5 points |
| 22/09/21 18:00 | 22/09/21 18:00 | OSC Lille | Stade Reims | 2-1 | 2 - 5 points |
| 22/09/21 18:00 | 22/09/21 18:00 | AS Monaco | AS St. Etienne | 3-1 | 2 - 5 points |
| 22/09/21 18:00 | 22/09/21 18:00 | HSC Montpellier | Girondins Bordeaux | 3-3 | 2 - 5 points |
| 22/09/21 20:00 | 22/09/21 20:00 | SCO Angers | Olympique Marseille | 0-0 | 2 - 5 points |
| 22/09/21 20:00 | 22/09/21 20:00 | RC Lens | Racing Club Strasbourg | 0-1 | 2 - 5 points |
| 22/09/21 20:00 | 22/09/21 20:00 | FC Lorient | OGC Nice | 1-0 | 2 - 5 points |
| 22/09/21 20:00 | 22/09/21 20:00 | Olympique Lyon | ES Troyes AC | 3-1 | 2 - 5 points |
| 22/09/21 20:00 | 22/09/21 20:00 | FC Metz | Paris St. Germain | 1-2 | 2 - 5 points |