Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 20/04/22 18:00 | 20/04/22 18:00 | AS Monaco | OGC Nice | 1-0 | 2 - 5 points |
| 20/04/22 18:00 | 20/04/22 18:00 | Stade Reims | OSC Lille | 2-1 | 2 - 5 points |
| 20/04/22 18:00 | 20/04/22 18:00 | ES Troyes AC | Clermont Foot | 0-1 | 2 - 5 points |
| 20/04/22 18:00 | 20/04/22 18:00 | Girondins Bordeaux | AS St. Etienne | 2-2 | 2 - 5 points |
| 20/04/22 18:00 | 20/04/22 18:00 | FC Lorient | FC Metz | 1-0 | 2 - 5 points |
| 20/04/22 20:00 | 20/04/22 20:00 | Racing Club Strasbourg | Stade Rennes | 2-1 | 2 - 5 points |
| 20/04/22 20:00 | 20/04/22 20:00 | SCO Angers | Paris St. Germain | 0-3 | 2 - 5 points |
| 20/04/22 20:00 | 20/04/22 20:00 | Stade Brest 29 | Olympique Lyon | 2-1 | 2 - 5 points |
| 20/04/22 20:00 | 20/04/22 20:00 | RC Lens | HSC Montpellier | 2-0 | 2 - 5 points |
| 20/04/22 20:00 | 20/04/22 20:00 | Olympique Marseille | FC Nantes | 3-2 | 2 - 5 points |