Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 01/12/21 18:00 | 01/12/21 18:00 | SCO Angers | AS Monaco | 1-3 | 2 - 5 points |
| 01/12/21 18:00 | 01/12/21 18:00 | Stade Brest 29 | AS St. Etienne | 1-0 | 2 - 5 points |
| 01/12/21 18:00 | 01/12/21 18:00 | FC Metz | HSC Montpellier | 1-3 | 2 - 5 points |
| 01/12/21 18:00 | 01/12/21 18:00 | Racing Club Strasbourg | Girondins Bordeaux | 5-2 | 2 - 5 points |
| 01/12/21 18:00 | 01/12/21 18:00 | ES Troyes AC | FC Lorient | 2-0 | 2 - 5 points |
| 01/12/21 20:00 | 01/12/21 20:00 | Clermont Foot | RC Lens | 2-2 | 2 - 5 points |
| 01/12/21 20:00 | 01/12/21 20:00 | Olympique Lyon | Stade Reims | 1-2 | 2 - 5 points |
| 01/12/21 20:00 | 01/12/21 20:00 | FC Nantes | Olympique Marseille | 0-1 | 2 - 5 points |
| 01/12/21 20:00 | 01/12/21 20:00 | Stade Rennes | OSC Lille | 1-2 | 2 - 5 points |
| 01/12/21 20:05 | 01/12/21 20:05 | Paris St. Germain | OGC Nice | 0-0 | 2 - 5 points |