Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 29/10/21 20:00 | 29/10/21 20:00 | Paris St. Germain | OSC Lille | 2-1 | 2 - 5 points |
| 30/10/21 16:00 | 30/10/21 16:00 | FC Metz | AS St. Etienne | 1-1 | 2 - 5 points |
| 30/10/21 20:00 | 30/10/21 20:00 | Olympique Lyon | RC Lens | 2-1 | 2 - 5 points |
| 31/10/21 12:00 | 31/10/21 12:00 | SCO Angers | OGC Nice | 1-2 | 2 - 5 points |
| 31/10/21 14:00 | 31/10/21 14:00 | Racing Club Strasbourg | FC Lorient | 4-0 | 2 - 5 points |
| 31/10/21 14:00 | 31/10/21 14:00 | ES Troyes AC | Stade Rennes | 2-2 | 2 - 5 points |
| 31/10/21 14:00 | 31/10/21 14:00 | Girondins Bordeaux | Stade Reims | 3-2 | 2 - 5 points |
| 31/10/21 14:00 | 31/10/21 14:00 | HSC Montpellier | FC Nantes | 2-0 | 2 - 5 points |
| 31/10/21 16:05 | 31/10/21 16:05 | Stade Brest 29 | AS Monaco | 2-0 | 2 - 5 points |
| 31/10/21 19:45 | 31/10/21 19:45 | Clermont Foot | Olympique Marseille | 0-1 | 2 - 5 points |