Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 22/10/21 21:00 | 22/10/21 21:00 | AS St. Etienne | SCO Angers | 2-2 | 2 - 5 points |
| 23/10/21 16:00 | 23/10/21 16:00 | FC Nantes | Clermont Foot | 2-1 | 2 - 5 points |
| 23/10/21 20:00 | 23/10/21 20:00 | OSC Lille | Stade Brest 29 | 1-1 | 2 - 5 points |
| 24/10/21 12:00 | 24/10/21 12:00 | OGC Nice | Olympique Lyon | 3-2 | 2 - 5 points |
| 24/10/21 14:00 | 24/10/21 14:00 | Stade Reims | ES Troyes AC | 1-2 | 2 - 5 points |
| 24/10/21 14:00 | 24/10/21 14:00 | Stade Rennes | Racing Club Strasbourg | 1-0 | 2 - 5 points |
| 24/10/21 14:00 | 24/10/21 14:00 | RC Lens | FC Metz | 4-1 | 2 - 5 points |
| 24/10/21 14:00 | 24/10/21 14:00 | FC Lorient | Girondins Bordeaux | 1-1 | 2 - 5 points |
| 24/10/21 16:00 | 24/10/21 16:00 | AS Monaco | HSC Montpellier | 3-1 | 2 - 5 points |
| 24/10/21 19:45 | 24/10/21 19:45 | Olympique Marseille | Paris St. Germain | 0-0 | 2 - 5 points |