Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 04/10/22 17:45 | 04/10/22 17:45 | FC Bayern Munich | Viktoria Plzen | Group C | 5-0 | 2 - 4 points |
| 04/10/22 18:05 | 04/10/22 18:05 | Olympique Marseille | Sporting Lisbon | Group D | 4-1 | 2 - 4 points |
| 04/10/22 20:00 | 04/10/22 20:00 | Liverpool FC | Glasgow Rangers | Group A | 2-0 | 2 - 4 points |
| 04/10/22 20:00 | 04/10/22 20:00 | Ajax Amsterdam | SSC Napoli | Group A | 1-6 | 2 - 4 points |
| 04/10/22 20:00 | 04/10/22 20:00 | Club Brugge | Atletico Madrid | Group B | 2-0 | 2 - 4 points |
| 04/10/22 20:00 | 04/10/22 20:00 | FC Porto | Bayer 04 Leverkusen | Group B | 2-0 | 2 - 4 points |
| 04/10/22 20:00 | 04/10/22 20:00 | Inter Milan | FC Barcelona | Group C | 1-0 | 2 - 4 points |
| 04/10/22 20:00 | 04/10/22 20:00 | Eintracht Frankfurt | Tottenham Hotspur | Group D | 0-0 | 2 - 4 points |
| 05/10/22 17:45 | 05/10/22 17:45 | RB Leipzig | Celtic Glasgow | Group F | 3-1 | 2 - 4 points |
| 05/10/22 17:45 | 05/10/22 17:45 | FC Red Bull Salzburg | Dinamo Zagreb | Group E | 1-0 | 2 - 4 points |
| 05/10/22 20:00 | 05/10/22 20:00 | Real Madrid | Schachtjor Donezk | Group F | 2-1 | 2 - 4 points |
| 05/10/22 20:00 | 05/10/22 20:00 | FC Sevilla | Borussia Dortmund | Group G | 1-4 | 2 - 4 points |
| 05/10/22 20:00 | 05/10/22 20:00 | Manchester City | FC Copenhagen | Group G | 5-0 | 2 - 4 points |
| 05/10/22 20:00 | 05/10/22 20:00 | Juventus Turin | Maccabi Haifa | Group H | 3-1 | 2 - 4 points |
| 05/10/22 20:00 | 05/10/22 20:00 | Benfica Lisbon | Paris St. Germain | Group H | 1-1 | 2 - 4 points |
| 05/10/22 20:00 | 05/10/22 20:00 | Chelsea FC | AC Milan | Group E | 3-0 | 2 - 4 points |