Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/12/21 17:30 | 10/12/21 17:25 | FC Schalke 04 | 1. FC Nürnberg | 4-1 | 1 - 3 points |
| 10/12/21 17:30 | 10/12/21 17:25 | Jahn Regensburg | Werder Bremen | 2-3 | 1 - 3 points |
| 11/12/21 12:30 | 11/12/21 12:25 | Holstein Kiel | SV Sandhausen | 2-2 | 1 - 3 points |
| 11/12/21 12:30 | 11/12/21 12:25 | SC Paderborn 07 | SV Darmstadt 98 | 0-1 | 1 - 3 points |
| 11/12/21 12:30 | 11/12/21 12:25 | FC Ingolstadt | Hannover 96 | 1-2 | 1 - 3 points |
| 11/12/21 19:30 | 11/12/21 19:25 | Fortuna Düsseldorf | FC St. Pauli | 1-1 | 1 - 3 points |
| 12/12/21 12:30 | 12/12/21 12:25 | Hamburger SV | FC Hansa Rostock | 3-0 | 1 - 3 points |
| 12/12/21 12:30 | 12/12/21 12:25 | Karlsruher SC | 1. FC Heidenheim 1846 | 3-2 | 1 - 3 points |
| 12/12/21 12:30 | 12/12/21 12:25 | Erzgebirge Aue | Dynamo Dresden | 0-1 | 1 - 3 points |