Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 15/10/21 17:30 | 15/10/21 17:25 | SC Paderborn 07 | Jahn Regensburg | 1-1 | 1 - 3 points |
| 15/10/21 17:30 | 15/10/21 17:25 | Hannover 96 | FC Schalke 04 | 0-1 | 1 - 3 points |
| 16/10/21 12:30 | 16/10/21 12:25 | 1. FC Heidenheim 1846 | FC St. Pauli | 2-4 | 1 - 3 points |
| 16/10/21 12:30 | 16/10/21 12:25 | FC Ingolstadt | Holstein Kiel | 1-1 | 1 - 3 points |
| 16/10/21 12:30 | 16/10/21 12:25 | Karlsruher SC | Erzgebirge Aue | 2-1 | 1 - 3 points |
| 16/10/21 19:30 | 16/10/21 19:25 | Hamburger SV | Fortuna Düsseldorf | 1-1 | 1 - 3 points |
| 17/10/21 12:30 | 17/10/21 12:25 | SV Darmstadt 98 | Werder Bremen | 3-0 | 1 - 3 points |
| 17/10/21 12:30 | 17/10/21 12:25 | Dynamo Dresden | 1. FC Nürnberg | 0-1 | 1 - 3 points |
| 17/10/21 12:30 | 17/10/21 12:25 | FC Hansa Rostock | SV Sandhausen | 1-1 | 1 - 3 points |