Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | FC Rot-Weiß Koblenz | Jahn Regensburg | 0-3 | 1 point |
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | Türkgücü München | 1. FC Union Berlin | 0-1 | 1 point |
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | SV Elversberg | FSV Mainz 05 | 9-10a.PSO | 1 point |
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | FC Carl Zeiss Jena | 1. FC Köln | 3-5a.PSO | 1 point |
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | SV Meppen | Hertha BSC | 0-1 | 1 point |
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | VfL Oldenburg | Fortuna Düsseldorf | 0-5 | 1 point |
| DFB | 08/08/21 14:30 | 08/08/21 14:30 | FC 08 Villingen | FC Schalke 04 | 1-4 | 1 point |
| DFB | 08/08/21 17:30 | 08/08/21 17:30 | Eintracht Braunschweig | Hamburger SV | 1-2 | 1 point |
| DFB | 08/08/21 17:30 | 08/08/21 17:30 | FC Würzburger Kickers | SC Freiburg | 0-1 | 1 point |
| DFB | 08/08/21 17:30 | 08/08/21 17:30 | FC Hansa Rostock | 1. FC Heidenheim 1846 | 3-2a.e.t | 1 point |
| DFB | 09/08/21 17:30 | 09/08/21 17:30 | FC Viktoria Köln | 1899 Hoffenheim | 2-3a.e.t | 1 point |
| DFB | 09/08/21 17:30 | 09/08/21 17:30 | Sportfreunde Lotte | Karlsruher SC | 1-4 | 1 point |
| DFB | 09/08/21 17:30 | 09/08/21 17:30 | FC Ingolstadt | Erzgebirge Aue | 2-1 | 1 point |
| DFB | 09/08/21 19:45 | 09/08/21 19:45 | 1. FC Kaiserslautern | Bor. Mönchengladbach | 0-1 | 1 point |