Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| DFB | 26/10/21 17:30 | 26/10/21 17:30 | Preußen Münster | Hertha BSC | 1-3 | 3 - 5 points |
| DFB | 26/10/21 17:30 | 26/10/21 17:30 | SV Babelsberg 03 | RB Leipzig | 0-1 | 3 - 5 points |
| DFB | 26/10/21 17:30 | 26/10/21 17:30 | TSV 1860 Munich | FC Schalke 04 | 1-0 | 3 - 5 points |
| DFB | 26/10/21 17:30 | 26/10/21 17:30 | 1899 Hoffenheim | Holstein Kiel | 5-1 | 3 - 5 points |
| DFB | 26/10/21 19:00 | 26/10/21 19:00 | Borussia Dortmund | FC Ingolstadt | 2-0 | 3 - 5 points |
| DFB | 26/10/21 19:45 | 26/10/21 19:45 | 1. FC Nürnberg | Hamburger SV | 3-5a.PSO | 3 - 5 points |
| DFB | 26/10/21 19:45 | 26/10/21 19:45 | FSV Mainz 05 | Arminia Bielefeld | 3-2a.e.t | 3 - 5 points |
| DFB | 26/10/21 19:45 | 26/10/21 19:45 | VfL Osnabrück | SC Freiburg | 4-5a.PSO | 3 - 5 points |
| DFB | 27/10/21 17:30 | 27/10/21 17:30 | Dynamo Dresden | FC St. Pauli | 2-3a.e.t | 3 - 5 points |
| DFB | 27/10/21 17:30 | 27/10/21 17:30 | SV Waldhof Mannheim | 1. FC Union Berlin | 1-3a.e.t | 3 - 5 points |
| DFB | 27/10/21 17:30 | 27/10/21 17:30 | Bayer 04 Leverkusen | Karlsruher SC | 1-2 | 3 - 5 points |
| DFB | 27/10/21 17:30 | 27/10/21 17:30 | VfL Bochum | FC Augsburg | 7-6a.PSO | 3 - 5 points |
| DFB | 27/10/21 19:45 | 27/10/21 19:45 | Bor. Mönchengladbach | FC Bayern Munich | 5-0 | 3 - 5 points |
| DFB | 27/10/21 19:45 | 27/10/21 19:45 | Hannover 96 | Fortuna Düsseldorf | 3-0 | 3 - 5 points |
| DFB | 27/10/21 19:45 | 27/10/21 19:45 | Jahn Regensburg | FC Hansa Rostock | 5-7a.PSO | 3 - 5 points |
| DFB | 27/10/21 19:45 | 27/10/21 19:45 | VfB Stuttgart | 1. FC Köln | 0-2 | 3 - 5 points |