Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| GER1 | 24/09/21 19:30 | 24/09/21 19:30 | SpVgg Greuther Fürth | FC Bayern Munich | 1-3 | 3 - 5 points |
| PL | 25/09/21 12:30 | 25/09/21 12:30 | Chelsea FC | Manchester City | 0-1 | 3 - 5 points |
| GER1 | 25/09/21 14:30 | 25/09/21 14:30 | Eintracht Frankfurt | 1. FC Köln | 1-1 | 3 - 5 points |
| GER1 | 25/09/21 14:30 | 25/09/21 14:30 | RB Leipzig | Hertha BSC | 6-0 | 3 - 5 points |
| GER1 | 25/09/21 14:30 | 25/09/21 14:30 | 1899 Hoffenheim | VfL Wolfsburg | 3-1 | 3 - 5 points |
| GER1 | 25/09/21 14:30 | 25/09/21 14:30 | 1. FC Union Berlin | Arminia Bielefeld | 1-0 | 3 - 5 points |
| GER1 | 25/09/21 14:30 | 25/09/21 14:30 | Bayer 04 Leverkusen | FSV Mainz 05 | 1-0 | 3 - 5 points |
| GER1 | 25/09/21 17:30 | 25/09/21 17:30 | Bor. Mönchengladbach | Borussia Dortmund | 1-0 | 3 - 5 points |
| MLS | 26/09/21 01:00 | 26/09/21 01:00 | New York City FC | New York Red Bulls | 0-1 | 3 - 5 points |
| GER1 | 26/09/21 14:30 | 26/09/21 14:30 | VfL Bochum | VfB Stuttgart | 0-0 | 3 - 5 points |
| GER1 | 26/09/21 16:30 | 26/09/21 16:30 | SC Freiburg | FC Augsburg | 3-0 | 3 - 5 points |
| FB | 26/09/21 18:30 | 26/09/21 18:30 | (GRE) PAOK Saloniki | (GRE) AEK Athen | 2-0 | 3 - 5 points |