| Date | Home | Away | Result |
|---|---|---|---|
| 15/10/26 17:45 | KF Egnatia | FC Midtjylland | 1-1 |
| 15/10/26 17:45 | FC Lugano | Red Star Belgrad | 3-2 |
| 15/10/26 17:45 | HNK Hajduk Split | Ajax Amsterdam | 2-1 |
| 15/10/26 17:45 | KAA Gent | Aarhus GF | 1-0 |
| 15/10/26 17:45 | Kuopion PS | Trabzonspor | 2-4 |
| 15/10/26 17:45 | Mjaellby AIF | Inter Escaldes | 2-0 |
| 15/10/26 17:45 | Panathinaikos Athens | FK Borac | 2-1 |
| 15/10/26 17:45 | ZSKA Sofia | AS Monaco | 1-2 |
| 15/10/26 17:45 | Riga FC | Kairat Almaty | 1-1 |
| 15/10/26 17:45 | Universitatea Craiova | FC Getafe | 1-1 |
| 15/10/26 20:00 | Atalanta Bergamo | Pafos FC | 3-1 |
| 15/10/26 20:00 | Brighton and Hove Albion | FK Kauno Zalgiris | 4-0 |
| 15/10/26 20:00 | FC Copenhagen | Sporting Braga | 3-0 |
| 15/10/26 20:00 | FC Twente Enschede | FC Thun | 1-0 |
| 15/10/26 20:00 | Heart of Midlothian | FC Nordsjaelland | 1-1 |
| 15/10/26 20:00 | Sint-Truidense VV | FC Iberia 1999 | 2-0 |
| 15/10/26 20:00 | SC Freiburg | FK Jablonec | 3-2 |
| 15/10/26 20:00 | Brann Bergen | Lincoln Red Imps FC | 2-1 |